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姓名: 袁红艳

性别: 女

职称: 讲师

是否博导: 否

最高学历: 研究生

最高学位: 博士

电话: 13904305422

邮箱: yuanhy@jlu.edu.cn

详细情况

所在学科专业:

免疫学

研究方向:

肿瘤免疫学

讲授课程:

医学免疫学,高级免疫学理论,高级免疫学实验技术,高级免疫学理论与技术

教育经历:

(1) 2001-09 2007-07, 吉林大学, 免疫学, 博士

(2) 1995-09 2000-06, 白求恩医科大学, 临床医学, 学士

工作经历:

(1) 2007-07 至今, 吉林大学, 免疫学系, 讲师

(2) 2005-09 2007-06, 吉林大学, 免疫学系, 助教

科研项目:

1. 吉林省科学技术厅,吉林省科学技术厅中青年科技创新创业卓越人才(团队)项目(创新类),20210509009RQ,炎症与免疫创新团队, 2021.07   2023.06,参与

2. HIF-α介导的糖酵解在MPLAR848联合诱导的M1型巨噬细胞极化及其抗肿瘤作用研究 吉林省科技厅国际合作处 20230402016GH 2023.01-2025.12,参与

学术论文:

1. Liu G, Zhang Z, Wu Y, Feng J,   Lan Y, Dong D, Liu Y, Yuan H, Tai G, Li S, Ni W. Anti-PD-L1 antibody reverses   the immune tolerance induced by multiple MUC1-MBP vaccine immunizations by increasing   the CD80/PD-L1 ratio, resulting in DC maturation, and decreasing Treg   activity in B16-MUC1 melanoma-bearing mice. Int Immunopharmacol. 2023 Aug; 121:110487.   doi: 10.1016/j.intimp.2023.110487. Epub 2023 Jun 24. PMID: 37364328.

2. Jie J, Liu G, Feng J, Huo D,   Wu Y, Yuan H, Tai G, Ni W. MF59 Promoted the Combination of CpG ODN1826 and   MUC1-MBP Vaccine-Induced Antitumor Activity Involved in the Enhancement of DC   Maturation by Prolonging the Local Retention Time of Antigen and   Down-Regulating of IL-6/STAT3. Int J Mol Sci. 2022 Sep 17;23(18):10887. doi:   10.3390/ijms231810887. PMID: 36142800; PMCID: PMC9501507.

3. Liu Y, Zhang Z, Sang Q, Zhang   Y, Jiang M, Zhou H, Wang J, Zhang N, Wu X, Zhou J, Ni W, Yuan H, Tai G.   Recombinant MUC1-MBP fusion protein combined with CpG2006 vaccine induces   antigen-specific CTL responses through cDC1-mediated cross-priming mainly   regulated by type I IFN signaling in mice. Immunol Lett. 2022 May;245:38-50.   doi: 10.1016/j.imlet.2022.04.002. Epub 2022 Apr 9. PMID: 35405170.

4. Wang J, Liu Y, Ni W, Wu X,   Zhou J, Zhang Z, Zhou H, Zhang N, Jiang M, Sang Q, Yuan H, Tai G.   TRAF6-overexpressing dendritic cells loaded with MUC1 peptide enhance   anti-tumor activity in B16-MUC1 melanoma-bearing mice. Int Immunopharmacol.   2022 Jun;107:108667. doi: 10.1016/j.intimp.2022.108667. Epub 2022 Mar 4.   PMID: 35255300.

5. Zhang Z, Zhou H, Liu Y, Ren   J, Wang J, Sang Q, Lan Y, Wu Y, Yuan H, Ni W, Tai G. Anti-PD1 antibody   enhances the anti-tumor efficacy of MUC1-MBP fusion protein vaccine via   increasing Th1, Tc1 activity and decreasing the proportion of MDSC in the   B16-MUC1 melanoma mouse model. Int Immunopharmacol. 2021 Dec;101(Pt   A):108173. doi: 10.1016/j.intimp.2021.108173. Epub 2021 Oct 1. PMID:   34607233.

著作教材:

1. 《常用免疫学实验技术(第2版)》杨巍、崔雪玲、夏圣、邝栋明主编,高等教育出版社,2024,参编

2. 《基础医学实验教程(第3版)》,李凡、季旻珺主编,高等教育出版社,2022,参编

3.《免疫学教程》,郭焱、李妍、许礼发主编,清华大学出版社,2015,参编

4.医学免疫学复习指南和题集》,吕昌龙、李一、任欢主编,高等教育出版社,2010,参编

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